Coevolution at the proteome scale - Institute for Protein Design

Product Description

Today we report in Science the identification of hundreds of previously uncharacterized protein–protein interactions in E. coli and the pathogenic bacterium M. tuberculosis. These include both previously unknown protein complexes and previously uncharacterized components of known complexes. This research was led by postdoctoral fellow Qian Cong and included former Baker lab graduate student Sergey Ovchinnikov, now a John Harvard Distinguished Science

Protein interaction networks revealed by proteome coevolution

PDF) ZEPPI: proteome-scale sequence-based evaluation of protein-protein interaction models

IPD Publication - Institute for Protein Design

News - Institute for Protein Design

Human mitochondrial protein complexes revealed by large-scale coevolution analysis and deep learning-based structure modeling

IJMS, Free Full-Text

Large-scale discovery of protein interactions at residue resolution using co-evolution calculated from genomic sequences

Structural prediction of protein interactions and docking using conservation and coevolution - Andreani - 2020 - WIREs Computational Molecular Science - Wiley Online Library

Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins